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List of publications involving Metabolomics


Curtasu, M. V., Obesity and metabolic syndrome in miniature pigs as models for human disease -metabolic changes in response to ad libitum feeding of high-fat-carbohydrate diets. Jun 2019, Aarhus University, Science and Technology. 209 p.  

Curtasu, Mihai Victor ; Knudsen, Knud Erik Bach; Callesen, Henrik; Purup, Stig; Stagsted, Jan; Hedemann, Mette SkouObesity development in a miniature Yucatan pig model – a multi-compartmental metabolomics study on cloned and normal pigs fed restricted or ad libitum high-energy diets.   I: Journal of Proteome Research, Bind 18, Nr. 1, 2019, s. 30-47.  

Sattari Najafabadi, Zahra; Nielsen, Tina Skau; Hedemann, Mette Skou.  Dietary protein source and butyrylated high-amylose maize starch included in a high-protein diet determines the urinary metabolome of rats.  I: International Journal of Food Sciences and Nutrition, Bind 70, Nr. 3, 2019, s. 255-266.

Nørskov, Natalja P.; Givens, Ian; Purup, Stig; Stergiadis, Sokratis. Concentrations of phytoestrogens in conventional, organic and free-range retail milk in England. /. I: Food Chemistry, Bind 295, 10.2019, s. 1-9.

Eriksen, Anne K; Kyrø, Cecilie; Nørskov, Natalja P; Frederiksen, Kirsten; Bach Knudsen, Knud-Erik; Overvad, Kim; Landberg, Rikard; Tjønneland, Anne; Olsen, Anja. Pre-diagnostic plasma enterolactone concentrations are associated with lower mortality among individuals with type 2 diabetes: a case-cohort study in the Danish Diet, Cancer and Health cohort. I: Diabetologia, Bind 62, Nr. 6, 06.2019, s. 959-969.

Nørskov, Natalja; Jensen, Søren Krogh; Sørensen, Martin Tang.Robust and highly sensitive micro Liquid Chromatography-tandem Mass Spectrometry method for analyses of polar pesticides (glyphosate, aminomethylphosfonic acid, N-acetyl glyphosate and N-acetyl aminomethylphosfonic acid) in multiple biological matrices. I: Journal of Chromatography A, 2019.

Publications 2017

Hedemann, M.S. (2017) The urinary metabolome in female mink (Mustela neovison) shows distinct changes in protein and lipid metabolism during the transition from diapause to implantation. Metabolomics 13:64 (https://link.springer.com/article/10.1007%2Fs11306-017-1200-4)

Hedemann, M.S, Hermansen, K., Pedersen, S., Bach Knudsen, K.E. (2017) Resistant starch but not enzymatic treated waxy maize delays development of diabetes in Zucker Diabetic Fatty rats. J. Nutr. 147: 825-834 (http://jn.nutrition.org/content/147/5/825)

Shokouh, P., Jeppsen, P.B., Hermansen, K., Nørskov, NP., Laustsen, C., Jacques Hamilton-Dutoit, S., Qi, M., Stødkilde-Jørgensen, H., Gregersen, S. (2017). A combination of coffee compounds shows insulin-sensitizing and hepatoprotective effects in a rat model of diet-induced metabolic syndrome. Nutrients (10) 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793234/

Bolvig, A. K., Nørskov, N.P., van Vliet, S., Foldager, L., Hedemann, M. S., Curtasu, M. V., Sørensen, J. F., Laerke, H. N., Knudsen, K. E. B. (2017). Rye bran modified with cell wall degrading enzymes influences the kinetics of plant lignans but not of enterolignans in multicatheterized pigs. The journal of nutrition 147 (12), 2220-2227. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941037/

Kyrø, C., Hansen, L., Frederiksen, K., Nørskov, N. P., Knudsen, K. E. B., Eriksen, A. K., Tjønneland, A., Holm, M., Olsen, A. (2017). Pre-diagnostic plasma enterolactone concentrations and breast cancer prognosis among postmenopausal women–The Danish Diet, Cancer and Health cohort. Journal of clinical nutrition S0261-5614 (17), 31396-  1. https://www.sciencedirect.com/science/article/pii/S0261561417313961?via%3Dihub

Eriksen, A. K., Kyrø, C., Nørskov, N. P., Bolvig, A. K., Christensen, J., Tjønneland A., Overvad, K., Landberg, R., Olsen, A. (2017). Prediagnostic enterolactone concentrations and mortality among Danish men diagnosed with prostate cancer. European journal of clinical nutrition 71 (10), 1235-1240. https://www.nature.com/articles/ejcn201742

Bolvig, A. K., Nørskov, N.P., Hedemann, M. S., Foldager, L., McCarthy-Sinclair, B., Marco, M. L:, Laerke, H. N., Knudsen, K. E. B. (2017). The effect of antibiotics and diet on enterolactone concentration and metabolome studied by targeted and non-targeted LC-MS metabolomics. Journal of Proteome Research 16(6), 2135-2150. https://pubs.acs.org/doi/10.1021/acs.jproteome.6b00942

Nørgaard, J.V., Soumeh, E.A., Curtasu, M., Corrent, E., van Milgen, J., Hedemann, M.S. (2017) Use of metabolic profile in short-term studies for estimating optimum dietary isoleucine, leucine, and valine for pigs. Anim. Feed Sci. Technol. 228: 39-47 (http://www.sciencedirect.com/science/article/pii/S0377840116310902)



Publications 2016

Curtasu, M.V., Theil, P.K., Hedemann, M.S. (2016) Metabolomic profiles of colostrum and milk from lactating sows. J. Anim. Sci. 94:272-275 


Nørskov, N.P., Kyrø, C.,Olsen, A.,Tjønneland, A., Knudsen, K. E. B. (2016). High-Throughput LC-MS/MS Method for Direct Quantification of Glucuronidated, Sulfated, and Free Enterolactone in Human Plasma. Journal of Proteome Research 15(3), 1051-1058.

Knudsen, K. E. B., Nørskov, N.P.Bolvig, A. K., Laerke, H. N. (2016). Dietary Fibers and Associated Phytochemicals in cereals.. Molecular Nutrition and Food Research 61(7), 1600518-1600534.

Nørskov, N. P., Knudsen, K. E. B. (2016). Validated LC-MS/MS method for quantification of free and bound lignans in cereal based diets and feces. Journal of Agricultural and Food Chemistry 64(44), 8343-8351.


Bolvig, A. K., Kyrø, C., Nørskov, N.P., Eriksen, A. K., Christensen, J., Tjønneland, A., Knudsen, K. E. B., Olsen, A. (2016). Use of antibiotics is associated with lower enterolactone plasma concentration. Molecular Nutrition & Food Research, 1-10.

Soumeh, E.A., Hedemann, M.S., Poulsen, H.D., Corrent, E.,  van Milgen, J., Nørgaard, J.V. (2016) Non-targeted LC-MS metabolomics approach for metabolic profiling of plasma and urine from pigs fed branched chain amino acids for maximum growth performance. J. Proteome Res. 15: 4195-4207 http://pubs.acs.org/doi/10.1021/acs.jproteome.6b00184

Publications 2015

Nørskov, N.P., Olsen, A., Tjønneland, A., Bolvig, A. K., Laerke, H. N., Knudsen, K. E. B. (2015). Targeted LC-MS/MS Method for the Quantitation of Plant Lignans and Enterolignans in Biofluids from Humans and Pigs. Journal of Agricultural and Food Chemistry 63(27), 6283-6292. 

Karaman, I., Nørskov, N.P., Yde, C. C., Hedemann, M. S., Knudsen, K. E. B.(2015). Sparse multi-block PLSR for biomarker discovery when integrating data from LC-MS and NMR metabolomics Metabolomics 11(2), 367-379. 
Nielsen, T. S., Theil, P. K., Purup, S., Nørskov, N.P., Knudsen, K. E. B. (2015). Effects of Resistant Starch and Arabinoxylan on Parameters Related to Large Intestinal and Metabolic Health in Pigs Fed Fat-Rich Diets Journal of Agricultural and Food Chemistry 63(48), 10418-10430.

Ingerslev, A.K., Karaman, I., Bağcıoğlu, M., Kohler, A., Theil, P.K., Bach Knudsen, K.E., Hedemann, M.S (2015) Whole Grain Consumption Increases Gastrointestinal Content of Sulfate-Conjugated Oxylipins in Pigs − A Multicompartmental Metabolomics Study. J. Proteome Res. 14, 3095-3110 http://pubs.acs.org/doi/10.1021/acs.jproteome.5b00039

Hedemann, M.S., Theil, P.K., Lærke, H.N., Bach Knudsen, K.E. (2015) Distinct Difference in Absorption Pattern in Pigs of Betaine Provided as a Supplement or Present Naturally in Cereal Dietary Fiber. J. Agric. Food Chem. 63, 2725-2733 (http://pubs.acs.org/doi/10.1021/jf506024v)

Publications 2014

Nielsen, K.L., Hartvigsen, M.L., Hedemann, M.S., Lærke, H.N., Hermansen, K., Bach Knudsen, K.E. (2014) Similar metabolic responses in pigs and humans to breads with different contents and compositions of dietary fibers: a metabolomics study. Am. J. Clin. Nutr. 99: 941-949 http://ajcn.nutrition.org/content/99/4/941

Nielsen, K.L., Hedemann, M.S., Lærke, H.N., Jørgensen, H., Bach Knudsen, K.E. (2014) A metabolomics approach used to profile plasma form portal-arterial pigs revealed differences between breads incurred by dietary fibre and protein contents. J. Nutr. Sci. 3, e18 https://www.cambridge.org/core/journals/journal-of-nutritional-science/article/metabolomics-approach-used-to-profile-plasma-from-portalarterial-pigs-revealed-differences-between-breads-incurred-by-dietary-fibre-and-protein-contents/77A40F69D18AB7B392FE3E4B54AB9FF2

Sugiharto, S., Jensen, B.B., Hedemann, M.S., Lauridsen, C. (2014) Comparison of casein and whey in diets on performance, immune responses and metabolomic profile of weanling pigs challenged with E. coli F4. Can. J. Anim. Sci. 94: 479-491 http://www.nrcresearchpress.com/doi/abs/10.4141/cjas2013-178#.WjD0AkqnG70

Sugiharto, S., Hedemann, M.S., Lauridsen, C. (2014) Plasma metabolomics profiles and immune responses of piglets after weaning and challenge with E. coli. J. Anim. Sci. Biotechnol. 5: 17 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995590/

Publications 2013

Nørskov, N.P., Hedemann, M. S., Laerke, H. N., Knudsen, K. E. B. (2013). Multicompartmental Nontargeted LC-MS Metabolomics: Explorative Study on the Metabolic Responses of Rye Fiber versus Refined Wheat Fiber Intake in Plasma and Urine of Hypercholesterolemic Pigs. Journal of Proteome Research 12(6), 2818 2832. https://www.ncbi.nlm.nih.gov/pubmed/23596967

Nørskov, N.P., Hedemann, M. S., Tjele, P. K., Fomsgaard, I. S., Laursen, B. B.; Knudsen, K. E. B. (2013). Phenolic Acids from Wheat Show Different Absorption Profile in Plasma: A Model Experiment with Catheterized Pigs. Journal of Agricultural and Food Chemistry 61, 8842-8850. 

Nørskov, N.P., Hedemann, M. S., Theil, P. K., Knudsen, K. E. B. (2013). Oxylipins discriminate between whole grain wheat and wheat aleurone intake: a metabolomics study on pig plasma. Metabolomics 9(2), 464-479. 

Publications 2012

Christensen, K.L., Hedemann, M.S., Jørgensen, H., Stagsted, J., Bach Knudsen, K.E. (2012) Liquid chromatography-mass spectrometry based metabolomics study of cloned versus normal pigs fed either restricted or ad libitum high-energy diets. J. Proteome Res. 11, 3573-3580 http://pubs.acs.org/doi/10.1021/jf400965j

Hedemann, M.S., Damgaard, B.M. (2012) Metabolomic study of plasma from female mink (Neovison vison) with low and high residual feed intake during restrictive and ad libitum feeding. Comp. Biochem. Physiol. D, 7: 322-327 http://www.sciencedirect.com/science/article/pii/S1744117X12000482?via%3Dihub

Hedemann, M.S., Flummer, C., Kristensen, N.B., Theil, P.K. (2012) Metabolic profiling of plasma from sows before parturition and during lactation using a liquid chromatography-mass spectrometry-based approach. J. Anim. Sci. 90 (suppl. 4): 200-202. 

Sugiharto, S., Hedemann, M.S., Jensen, B.B., Lauridsen, C. (2012) Diarrhea-like condition and intestinal mucosal responses in susceptible homozygous and heterozygous F4R+ pigs challenged with enterotoxigenic Escherichia coli. J. Anim. Sci. 90 (suppl. 4) 281-283